Scientist II, Degrader Antibody Conjugate Characterization

Position

You will lead the development of innovative analytical workflows that support and accelerate Nurix's DAC platform, applying your expertise in ADC and/or DAC characterization to solve complex scientific challenges. This is an opportunity to shape analytical strategy for a novel therapeutic platform at the forefront of drug discovery and development.

This is a laboratory role requiring assay design, method development, hands-on execution, and scientific communication to project and platform teams. You will design and execute analytical strategies for high-throughput DAC screening, establish quality criteria that drive conjugate advancement decisions, and partner closely with conjugation chemistry, biology, and bioanalytical teams from early screening through candidate selection.

Responsibilities:

• Design, execute and own the DAC screening characterization platform including DAR, aggregation, protein quantitation, and define the QC thresholds to advance conjugates for a program
• Lead and conduct in-depth characterization of antibodies and advanced DACs including positional isomers, glycosylation analysis, peptide mapping, and stability
• Integrate DAR, purity, hydrophobicity, and stability data into unified assessments with QC cutoffs that drive go/no-go decisions; identify structure-quality trends across antibody, linker, and payload variables
• Develop, optimize, and troubleshoot LCMS and HPLC methods for throughput and robustness; establish plate-based sample preparation workflows that maintain data quality at screening scale
• Present findings to project and platform teams; collaborate with conjugation chemistry, bioanalytical, and cell screening groups to align workflows, coordinate sample flow, and influence conjugate advancement decisions

Requirements:

• BS/BA with 12+, MS/MA with 8+, or PhD with 4+ years of industry experience in biochemistry, analytical chemistry, or a related discipline
• Expertise in ADC/DAC and antibody characterization from method development to data interpretation
• Expertise with LCMS and HPLC methods for antibody and conjugate analysis, including DAR, SEC, peptide mapping, HIC, and other relevant industry leading methods
• Direct experience characterizing ADCs in an industry setting with working knowledge of conjugation chemistry, DAR heterogeneity, and common quality attributes
• Track record of independently designing experiments, developing analytical methods, troubleshooting assay and instrument performance, and managing priorities across multiple concurrent programs
• Ability to synthesize complex analytical datasets into actionable scientific conclusions and influence project decisions through clear communication to cross-functional teams

Preferred Qualifications

• Experience with native LCMS, positional isomer analysis, glycan analysis, CE-SDS for expanded conjugate or antibody characterization
• Background in peptide mapping, biophysical binding assays, and thermal stability
• Familiarity with developability assessment, forced degradation, or formulation-support analytics for biologics
• Familiarity and experience with Agilent instrumentation and analytical software (MassHunter, Byos, or equivalent)

Culture & Team Fit:

• Ability to work collaboratively across multiple groups within the organization
• Excellent organization and communication with effective presentation skills
• Self-driven and enthusiastic with proficiencies to deliver in a dynamic environment
• Curious mindset with a willingness and flexibility to learn new skills
• High level of creativity and productivity with strong problem-solving skills